In this optical video snapshot, a tetherless microgripper grabs onto a clump of live L929 animals cells placed at the end of a narrow glass capillary tube.
In the not-too-distant future, your surgeon may be someone who -- instead of wielding a scalpel -- injects you with a flock of dust-sized wireless devices that grab and remove infected or damaged tissue in response to chemical signals.
These microgrippers, less than 1/254th of an inch (1/10th of a millimeter) in diameter, have been developed by researchers at John Hopkins University, and tested in biopsy-like procedures with animal tissue. One writer described them as working like a hand: a "palm" surrounded by six "fingers" that can open and close around an object.
The crab-like devices are moved and guided by external magnets, and grab or release in response to non-toxic biochemicals or temperature changes. By contrast, today's generation of microgrippers are physically controlled via thin wires or tubes, which make it difficult to maneuver the devices through convoluted twists and turns.
The microgrippers created at Hopkins have gold-plated nickel, so magnets outside the body can be used to move and guide the devices remotely, over relatively long distances.
The bioengineering project was directed by David Gracias, assistant professor of chemical and biomolecular engineering at the university's Whiting School of Engineering. His lab's focus is on applying the science of miniaturization to the interface between engineered and biological systems.
Results of experiments using the new crop of wireless microgrippers were reported in the online Jan. 12 to 16 Early Edition of "Proceedings of the National Academy of Sciences." The lead author of the paper is Timothy Leong, along with Gracias and co-authors Christina Randall, Brian Benson, Noy Bassik and George Stern, all students supervised by Gracias.
The John Hopkins Technology Transfer staff has obtained a provisional U.S. patent covering the team's inventions, and is seeking patent protection.
Gracias sees the devices as the first generation of technologies that could eventually result in autonomous micro- and nano-scale surgical tools, inexpensively reproducible on a mass scale, that could help doctors in diagnosing and treating a range of illnesses much less invasively than is possible today.
This optical microscopy image shows a tetherless microgripper holding on to a piece of bovine bladder tissue retrieved from a tissue sample placed at the end of a narrow glass capillary tube.